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Female libido. Latest News: The eight-week study
found that Viagra, also known as sildenafil, helped women achieve
orgasm.
"In this study population, sildenafil treatment of sexual
dysfunction in women taking SRIs was associated with a reduction in
adverse sexual effects," the study's authors wrote.
Results of the study are in the July 23/30 issue of the
Journal of the
American Medical Association. The lead author of the
study, Dr. H. George Nurnberg, of the
University of New Mexico School of Medicine, in
Albuquerque,
declined to be interviewed for this article.
Selective and nonselective serotonin reuptake inhibitors, such as
Prozac, Paxil, Zoloft and Effexor, comprise up to 90 percent of the
180 million antidepressant prescriptions filled in the United States
each year, according to the study. But while these medications are
very effective at treating clinical depression, one of their known
drawbacks are sexual side effects.
Nurnberg and his colleagues previously reported in the
Journal of Clinical Psychiatry, that Viagra was helpful
for men who suffered from erectile dysfunction associated with the
use of antidepressant medications.
In the current study, undertaken at seven research centers, they
turned their attention to women. The study included 98 women -- half
of whom received Viagra and half who received a placebo -- who were
told to take the pills before sexual activity.
Women taking Viagra reported an improved ability to reach orgasm
and increased orgasm satisfaction, according to the study authors.
But 43 percent of the women taking Viagra also reported
headaches, versus 27 percent of those on placebo. Almost one-quarter
of those using Viagra reporting flushing, while none of the women on
placebo did. And 37 percent of women taking Viagra reported nasal
congestion compared to 6 percent of women on placebo. Nausea and
anxiousness were reported more often in the group taking placebo.
"The libido response in women is such a complex problem. If women
are unhappy in a relationship, it can affect libido. If it hurts, it
can affect libido. If she doesn't feel good about herself, it can
affect libido. It's hard to tease all of those factors out," said
Dr. Judi Chervenak, a reproductive endocrinologist at
Montefiore Medical Center in New York City.
And, she added, "There's no definitive answer to date on how
antidepressants cause a lack of libido. It could be because they're
affecting dopamine, and women may be experiencing changes in
dopamine that indirectly affect vaginal lubrication and arousal and
cause decreased blood flow."
Of the current study, Chervenak said, "It's an enticing study,
and it makes me want to know more. Does it make me want to prescribe
Viagra right off the bat? Not at this point. I'd suggest first that
patients keep a symptom diary, so we can figure out what their issue
is. Is it arousal? Is it decreased blood flow? Is it an orgasm
problem?"
"Another possibility might be to work with their psychiatrist,"
she added. "Would it be better to change the antidepressant or to
taper the dose? What about a drug holiday? Although you have to be
careful, and people can't do that on their own, because there can be
potentially devastating problems if you come off these medications
too quickly."
"This study has opened up many questions, and hopefully, we'll
learn more in the future," concluded Chervenak.
Meanwhile, a spokeswoman for
Pfizer, which manufactures Viagra, told the Associated
Press that the company has no plans to seek approval for using
the drug as a treatment for female sexual dysfunction. The company
ended its own research on Viagra for women in 2004, she added. |